Effect of static offsets on the nonlinear dynamic mechanical properties of human brain tissue. (June 2022)

• Record Type: Journal Article
• Authors: Ramorino, Giorgio; Gobetti, Anna; Cornacchia, Giovanna; Roca, Elena
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 130(2022)
• Publication Date: 2022-06
• Subjects: Brain tissue -- Dynamic characterization -- Payne effect -- Non-linear dynamic behaviour -- Storage modulus -- Loss modulus -- Superimposed static load -- Cellular environment; SCO Static Compression Offset -- G' Shear Storage Modulus -- G'' Shear Loss Modulus -- tanδ Loss Factor -- FFF Free-Flowing Fluid -- ECS Extracellular Space -- ECM Extracellular Matrix -- CSF Cerebrospinal Fluid -- LAM Low Amplitude Modulus -- HAM High Amplitude Modulus -- LAL Low Amplitude Loss Factor -- LVR Linear Viscoelastic Regime -- VSD Visloelastic Solid Domain; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2022.105204
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: This study focuses on the variations in the brain tissue dynamic behaviour pointing out new insight into the material nonlinear viscoelasticity. Shear dynamic response curves are obtained in different working conditions in terms of strain sweep and superimposed static compression offsets (SCO ) applied in orthogonal direction to the shear. The strain sweep mode is used to study the storage and loss moduli dependence on the amplitude of the applied strain. It is found that the material exhibits linear viscoelastic behaviour up to about 0.1% strain amplitude. Above this critical threshold, the storage modulus G′ decreases rapidly with increasing dynamic strain amplitude and this effect is gradually intensified as the SCO are increased. In addition, it is observed that the loss factor (G''/G′ ) increases by increasing the SCO applied to the specimens. The dynamic strain amplitude results of the storage modulus reveal that the elastic component of the brain tissue's stiffness (G′ ) evaluated at low strain strongly increases with increasing static superimposed compression strain while the loss factor in the same strain range appears to be SCO independent. Finally, dynamic stiffness recovery after a large strain deformation is considered. The reduction in low amplitude dynamic modulus and subsequent recovery kinetics due to a perturbation is found to be independent of the level of the SCO. The same assessments were carried out on 5 consecutive strain sweep cycle loading. It has been noticed that at the last cycle, the dissipation peak is reduced, and the non-linearity of the curve begins earlier. This could be explained by the effects of cerebral edema on cells and their surrounding environment. Graphical abstract: Image 1 Highlights: Brain tissue shows Payne effect similarly to filled elastomers. Payne effect could be related to proteins and cerebrospinal fluid rearrangement. Storage modulus at low strain increases with increasing static offset. Recovery kinetics could be considered pure-elastic and static offset independent. On 5 strain sweep cycles the accumulation of intra -extracellular fluids is supposed.