Trimethyl chitosan postoperative irrigation solution modulates inflammatory cytokines related to adhesion formation. (15th July 2022)

• Record Type: Journal Article
• Authors: Abueva, Celine DG.; Ryu, Hyun Seok; Park, So Young; Lee, Hayoung; Padalhin, Andrew R.; Min, Jun Won; Chung, Phil-Sang; Woo, Seung Hoon
• Is Part Of: Carbohydrate polymers. Volume 288(2022)
• Publication Date: 2022-07-15
• Subjects: Irrigation -- Anti-inflammatory -- Anti-adhesion -- Trimethyl chitosan -- Chitosan; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119380
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Lavage or irrigation has been instilled in surgical practice for wound clearance and surgical site infection prevention during and after surgery. Herein, we developed a new irrigation solution using trimethyl chitosan (TMC), a quaternized chitosan derivative. The TMC-saline irrigation solution developed in the study possesses highly effective bactericidal properties with hemostatic and anti-adhesion properties. The anti-adhesion property of TMC was investigated in relation to inflammatory cytokine response and wound healing. TMC-saline irrigation solution showed reduced pro-inflammatory cytokine protein and gene expressions relevant in the cascade of wound healing and cytokine-related orchestration of postoperative adhesion formation. Further development of this multifunctional TMC-saline irrigation solution can be beneficial for surgical applications and postoperative wound management. Graphical abstract: Unlabelled Image