Effect of Zn and Ga doping on bioactivity, degradation, and antibacterial properties of borate 1393-B3 bioactive glass. Issue 11 (1st June 2022)

• Record Type: Journal Article
• Authors: Mutlu, Nurshen; Kurtuldu, Fatih; Unalan, Irem; Neščáková, Zuzana; Kaňková, Hana; Galusková, Dagmar; Michálek, Martin; Liverani, Liliana; Galusek, Dušan; Boccaccini, Aldo R.
• Is Part Of: Ceramics international. Volume 48:Issue 11(2022)
• Page Start: 16404
• Page End: 16417
• Publication Date: 2022-06-01
• Subjects: Bioactive glasses -- Borate glasses -- Zinc -- Gallium -- Antibacterial activity; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2022.02.192
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Borate 1393-B3 bioactive glasses doped with ZnO or Ga2 O3 (1, 3, and 6% mol) were produced by conventional melt quenching. All doped glasses showed in-vitro bioactivity in simulated body fluid (SBF). For the first time, the dissolution behavior of the glasses both in phosphate-buffered saline (PBS) and cell culture medium was investigated. The ion release rate in the cell culture medium increased compared to that in PBS solution. All tested glass compositions, including the parent 1393-B3 glass, showed antibacterial effect against S. aureus and E. coli . The incorporation of Zn and Ga enhanced the viability of MG-63 osteoblast-like cells compared to the base 1393-B3 glass. The results show the potential of Zn and Ga-doped borate glasses in multifunctional tissue engineering applications.