Fast and accurate deformable contour propagation for intra-fraction adaptive magnetic resonance-guided prostate radiotherapy. (January 2022)

• Record Type: Journal Article
• Authors: Willigenburg, Thomas; Zachiu, Cornel; Lagendijk, Jan J.W.; van der Voort van Zyp, Jochem R.N.; de Boer, Hans C.J.; Raaymakers, Bas W.
• Is Part Of: Physics and imaging in radiation oncology. Volume 21(2022)
• Page Start: 62
• Page End: 65
• Publication Date: 2022-01
• Subjects: MRI-guided radiotherapy -- MR-guided linear accelerator -- Radiotherapy workflow -- Intra-fraction adaptation -- Prostate cancer; Radiotherapy -- Periodicals; Radiation dosimetry -- Periodicals; Cancer -- Imaging -- Periodicals; Oncology -- Periodicals; 615.842
• DOI: 10.1016/j.phro.2022.02.008
• Languages: English
• ISSNs: 2405-6316

Abstract

Highlights: Accurate contours are needed for intra-fraction adaption using contour propagation. A deformable image registration algorithm (EVolution) was tested for this purpose. Clinical quality of intra-fraction propagated contours was assessed by 2 physicians. EVolution provided good results in 10 prostate cancer cases. This paves the way for adaptive workflows using deformable contour propagation. Abstract: To facilitate full intra-fraction adaptive MR-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intra-fraction propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (≥ 97%), whereas rectum contours needed more extensive editing in 12–23%. Nevertheless, adaptation times were < 3 min for ≥ 93% of the cases. This paves the way for exploring adaptive workflows using intra-fraction deformable contour propagation.