Imidazolium chloride as an additive for synthesis of perimidines using 1, 8-diaminonaphthalene and DMF derivatives. (30th March 2022)

• Record Type: Journal Article
• Authors: Zhang, Xiuyu; Liao, Siwei; Liu, Aqin; Liu, Xiaoling; Kuang, Qiulin; Wang, Yin; Xu, Ping; Huang, Xin; Wu, Huili; Yuan, Jianyong
• Is Part Of: Tetrahedron letters. Volume 94(2022)
• Publication Date: 2022-03-30
• Subjects: 1, 8-Diaminonaphthalene -- Imidazolium chloride -- Perimidine -- DMF derivatives; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153701
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A facile universal and economical method for the synthesis of perimidine has been described via the imidazolium chloride-promoted cyclizaton of 1, 8-diaminonaphthalene with N, N-dimethylformamide (DMF) derivatives. This protocol showed a wide range of functional group tolerance, and a series of perimidines were synthesized in moderate to excellent yields without metal catalysts, solvent or other additives. A multi-gram scale reaction is also performed to ensure the scalability of the reaction.