Dehydrogenation of N‐Heterocyclic Compounds Using H2O2 and Mediated by Polar Solvents. Issue 6 (18th February 2022)

• Record Type: Journal Article
• Authors: Llopis, Natalia; Gisbert, Patricia; Baeza, Alejandro; Correa‐Campillo, Jara
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 6(2022)
• Page Start: 1205
• Page End: 1210
• Publication Date: 2022-02-18
• Subjects: Oxidation -- Dehydrogenation -- HFIP -- Hydrogen Peroxide -- N-Heterocycles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101360
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The oxidative dehydrogenation of N ‐heterocyclic compounds by using H2 O2 as oxidant in combination with polar solvents such as 1, 1, 1, 3, 3, 3‐hexafluoroisopropanol (HFIP) and H2 O is described. Among these two solvents, the best yields for the heteroaromatic compounds were generally achieved in HFIP. However, it is remarkable, that the use of a non toxic solvent such as H2 O gave such good yields. Furthermore, the procedure was implemented in larger‐scale and HFIP was distilled from the reaction mixture and reused (up to 5 cycles) without a significant detriment in the reaction outcome. Abstract :