MGluR5 and GABAA receptor‐specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application. Issue 7 (25th January 2022)

• Record Type: Journal Article
• Authors: Kaulen, Nicolas; Rajkumar, Ravichandran; Régio Brambilla, Cláudia; Mauler, Jörg; Ramkiran, Shukti; Orth, Linda; Sbaihat, Hasan; Lang, Markus; Wyss, Christine; Rota Kops, Elena; Scheins, Jürgen; Neumaier, Bernd; Ermert, Johannes; Herzog, Hans; Langen, Karl‐Joseph; Lerche, Christoph; Shah, N. Jon; Veselinović, Tanja; Neuner, Irene
• Is Part Of: Human brain mapping. Volume 43:Issue 7(2022)
• Page Start: 2148
• Page End: 2163
• Publication Date: 2022-01-25
• Subjects: GABAA -- mGluR5 -- multimodal imaging -- PET atlas construction; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25778
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: The glutamate and γ‐aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non‐displaceable binding potential ( BP ND ), and total distribution volume ( V T ) based on simultaneously acquired bolus‐infusion positron emission tomography (PET) and MR data. The pipeline was applied to [ 11 C]ABP688‐PET/MR (13 healthy male non‐smokers, 26.6 ± 7.0 years) and [ 11 C]Flumazenil‐PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V T and BP ND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET‐to‐PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [ 15 O]H2 O‐template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions. Abstract : In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non‐displaceable binding potential ( BP ND ), and total distribution volume ( V T ) based on simultaneously acquired bolus‐infusion positron emission tomography (PET) and magnetic resonance imaging (MR) data. The pipeline was applied to [ 11 C]ABP688‐PET/MR (13 healthy male non‐smokers, 26.6 ± 7.0 years) and [ 11 C]Flumazenil‐PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V T and BP ND atlases of mGluR5 and GABAA, were generated from these data.