Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons (Small 14/2022). Issue 14 (7th April 2022)

• Record Type: Journal Article
• Authors: Roversi, Katiane; Tabatabaei, Maryam; Desjardins‐Lecavalier, Nicolas; Balood, Mohammad; Crosson, Theo; Costantino, Santiago; Griffith, May; Talbot, Sebastien; Boutopoulos, Christos
• Is Part Of: Small. Volume 18:Issue 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-07
• Subjects: functionalized gold nanoparticles -- nanophotonics -- nociceptor neurons -- N‐type calcium channel blocker (CNCB‐2) -- photothermal silencing -- targeted drug delivery -- transient receptor potential vanilloid type 1 (TRPV1); Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202270067
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Nociceptor Neuron Silencing In article number 2103364, Sebastien Talbot, Christos Boutopoulos, and co‐workers report a nanotechnology‐enabled strategy to silence subsets of unmodified nociceptor neurons. It uses laser stimulation of neurons targeted with gold nanoparticles to heat‐activate TRPV1, turning this channel into a cell‐specific entry port for silencing drugs that block neuropeptide release (i.e., communication with other cells). This work establishes a paradigm for interfering with deleterious neuro‐immune interplays.