Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues. Issue 14 (25th February 2022)

• Record Type: Journal Article
• Authors: Zhang, Xiangyun; Zhang, Yue; Zhang, Ran; Jiang, Xinbang; Midgley, Adam C; Liu, Qiqi; Kang, Helong; Wu, Jin; Khalique, Anila; Qian, Meng; An, Di; Huang, Jing; Ou, Lailiang; Zhao, Qiang; Zhuang, Jie; Yan, Xiyun; Kong, Deling; Huang, Xinglu
• Is Part Of: Advanced materials. Volume 34:Issue 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-25
• Subjects: cell‐like delivery -- ferritin -- ischemic diseases -- nitric oxide -- vascular regeneration; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202110352
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Restoration of sufficient blood supply for the treatment of ischemia remains a significant scientific and clinical challenge. Here, a cell‐like nanoparticle delivery technology is introduced that is capable of recapitulating multiple cell functions for the spatiotemporal triggering of vascular regeneration. Specifically, a copper‐containing protein is successfully prepared using a recombinant protein scaffold based on a de novo design strategy, which facilitates the timely release of nitric oxide and improved accumulation of particles within ischemic tissues. Through closely mimicking physiological cues, the authors demonstrate the benefits of bioactive factors secreted from hypoxic stem cells on promoting angiogenesis. Following this cell‐mimicking manner, artificial hybrid nanosized cells (Hynocell) are constructed by integrating the hypoxic stem cell secretome into nanoparticles with surface coatings of cell membranes fused with copper‐containing protein. The Hynocell, hybridized with different cell‐derived components, provides synergistic effects on targeting ischemic tissues and promoting vascular regeneration in acute hindlimb ischemia and acute myocardial infarction models. This study offers new insights into the utilization of nanotechnology to potentiate the development of cell‐free therapeutics. Abstract : The use of stem cell‐based therapeutics faces some bottleneck problem in the progression of cellular approaches. This study introduces a cell‐like nanoparticle delivery system that is capable of recapitulating multiple cell functions, providing superior effects on targeting ischemic tissues and spatiotemporal triggering of vascular regeneration in ischemic tissues.