All‐In‐One Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for Synergistically Enhanced Radiotherapy of Colon Cancer. Issue 14 (12th February 2022)

• Record Type: Journal Article
• Authors: Gong, Liuyun; Zhang, Yujie; Zhao, Jing; Zhang, Yilei; Tu, Kangsheng; Jiao, Lianying; Xu, Qiuran; Zhang, Mingzhen; Han, Suxia
• Is Part Of: Small. Volume 18:Issue 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-12
• Subjects: biomimetic nanoplatforms -- hypoxia -- purine metabolism pathway -- radiosensitizers -- X‐ray induced photodynamic therapies; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202107656
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Even though radiotherapy is the most important therapeutic strategy for colon cancer treatment, there is an enormous demand to improve radiosensitivity in solid tumor destruction. For this purpose, a biomimetic nanoplatform based on hollow polydopamine nanoparticles (HP) with homologous targeting and pH‐responsive drug release properties is designed. In this work, HP is constructed by using a chelation competition‐induced polymerization strategy and then modified with the cancer cell membrane. Hollow polydopamine integrated with Pt nanoparticles (Pt@HP) has a catalase‐like activity, which can be used to trigger endogenous H2 O2 into O2, relieving hypoxia of the tumor microenvironment (TME). With mesoporous shells and large cavities, Pt@HP shows efficient apoptin 100–109 (AP) and verteporfin (VP) loading to form AVPt@HP@M. Under X‐ray irradiation, AVPt@HP@M exerts a radiosensitization effect via multiple strategies, including relieving hypoxia (Pt NPs), enhancing tumor apoptosis (AP), and X‐ray‐induced photodynamic therapy (X‐PDT) (VP). Further metabonomics analysis shows that the specific mechanism of the AVPt@HP@M is through influencing purine metabolism. Without appreciable systemic toxicity, this nanoplatform highlights a new strategy for effective radiosensitization and provides a reference for treating malignant tumors. Abstract : A hollow polydopamine embedded with platinum nanoparticle (Pt@HP) is synthesized, co‐loaded with apoptin 100–109 (AP) and verteporfin (VP), and then modified with the cancer cell membrane (M). This biomimetic nanoplatform (AVPt@HP@M) exerts sensitization to radiation therapy via multiple strategies, including relieving hypoxia (Pt NPs), enhancing tumor apoptosis (AP), and X‐PDT (VP).