Coupling of brain activity and structural network in multiple sclerosis: A graph frequency analysis study. Issue 5 (20th February 2022)

• Record Type: Journal Article
• Authors: Ye, Chenfei; Huang, Jing; Liang, Li; Yan, Zehong; Qi, Zhigang; Kang, Xiong; Liu, Zheng; Dong, Huiqing; Lv, Haiyan; Ma, Ting; Lu, Jie
• Other Names: Chanraud Sandra guestEditor.; Badaut Jerome guestEditor.
• Is Part Of: Journal of neuroscience research. Volume 100:Issue 5(2022)
• Page Start: 1226
• Page End: 1238
• Publication Date: 2022-02-20
• Subjects: brain structural network -- clinically isolated syndrome -- graph frequency analysis -- multiple sclerosis -- resting‐state fMRI; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.25028
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract: The brain activities and the underlying wiring diagrams are vulnerable in multiple sclerosis (MS). Also, it remains unknown whether the complex coupling between these functional and structural brain properties would be affected. To address this issue, we adopted graph frequency analysis to quantify the high‐order structural‐functional interactions based on a combination of brain diffusion and functional MRI data. The structural‐functional decoupling index was proposed to measure how much brain regional functional activity with different graph frequency was organized atop the underlying wiring diagram in MS. The identified patterns in MS included (1) disruption of inherent structural‐functional coupling in the somatomotor network ( β = 0.05, p = 0.03), and (2) excessive decrease of decoupling in the subcortical ( β = −0.10, p = 0.02), visual ( β = −0.04, p = 0.01), and dorsal attention networks ( β = −0.12, p = 0.03). Besides, this structural‐functional coupling signature in the somatomotor network was associated with cognitive worsening of MS patients ( β = −24.31, p = 0.006). Overall, our study unveiled a unique signature of brain structural‐functional reorganization in MS. Abstract : By quantitatively measuring the brain coupling signature between functional activity and structural connectome using graph frequency analysis, we found a unique signature of brain structural‐functional reorganization in multiple sclerosis.