Multimodal PSSMA‐Functionalized GdF3 : Eu3+(Tb3+) Nanoparticles for Luminescence Imaging, MRI, and X‐Ray Computed Tomography. Issue 8 (20th August 2019)

• Record Type: Journal Article
• Authors: Shapoval, Oleksandr; Kaman, Ondřej; Hromádková, Jiřina; Vavřík, Daniel; Jirák, Daniel; Machová, Daniela; Parnica, Jozef; Horák, Daniel
• Is Part Of: ChemPlusChem. Volume 84:Issue 8(2019)
• Page Start: 1135
• Page End: 1139
• Publication Date: 2019-08-20
• Subjects: biocompatible -- gadolinium fluoride -- luminescence -- magnetic resonance imaging -- x-ray computed tomography; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.201900352
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract: Biocompatible poly(4‐styrenesulfonic acid‐ co ‐maleic acid)‐stabilized GdF3 : Eu 3+ (Tb 3+ ) nanoparticles were obtained by a one‐step coprecipitation method in ethylene glycol or water. The particles are very small (3 nm), have a narrow size distribution, and were detectable by fluorescence, magnetic resonance, and X‐ray contrast imaging. These properties allow multimodal imaging, which has prospective applications in the simultaneous and detailed detection of diseased tissues. Abstract : Multifunctional nanoparticles with a narrow size distribution were prepared by coprecipitation method in ethylene glycol using poly(4‐styrenesulfonic acid‐ co ‐maleic acid) (PSSMA) as a stabilizer. Significant contrast enhancement of Eu‐ and Tb‐doped GdF3 @PSSMA nanoparticles was obtained in magnetic resonance imaging and X‐ray computed tomography. GdF3 : Eu 3+ (Tb 3+ )@PSSMA particles proved to be nontoxic and biocompatible and they facilitated entry into the living cells, demonstrating a strong, photostable and nonblinking fluorescence emission.