Chemical constituents from the branches and leaves of Alchornea annamica. Issue 9 (3rd May 2022)

• Record Type: Journal Article
• Authors: Phan, Nguyen Huu Toan; Thuan, Nguyen Thi Dieu; Hien, Nguyen Thi Thu; Huyen, Pham Van; Hanh, Tran Thi Hong; Quang, Tran Hong; Cuong, Nguyen Xuan; Nam, Nguyen Hoai
• Is Part Of: Natural product research. Volume 36:Issue 9(2022)
• Page Start: 2349
• Page End: 2355
• Publication Date: 2022-05-03
• Subjects: Alchornea annamica -- Euphorbiaceae -- megastigmane glycoside -- NO production; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1834552
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical investigation of the branches and leaves of Alchornea annamica led to isolation of ten secondary metabolites, including two new megastigmane glucosides alnamicosides A (1 ) and B (2 ). The structure elucidation was confirmed by 1 D and 2 D NMR, ECD as well as HR-QTOF-MS experiments. The megastigmane derivatives 1 − 3 exhibited inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC50 values of 78.72 ± 1.90, 77.40 ± 9.40 and 82.16 ± 4.56 µM, respectively. This is the first report on chemical constituents and biological activity of the plant A. annamica . Graphical Abstract: