Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study. (4th March 2022)

• Record Type: Journal Article
• Authors: Lu, Yanmei; Linpeng, Siyuan; Ding, Siyi; Li, Shihong; Shi, Liangcheng; Zuo, Xinwei; He, Jun; Liu, Yalan
• Is Part Of: Expert review of molecular diagnostics. Volume 22:Number 3(2022)
• Page Start: 387
• Page End: 394
• Publication Date: 2022-03-04
• Subjects: Noninvasive prenatal testing -- cell-free fetal DNA -- test failure -- follow-up -- pregnancy outcome; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1080/14737159.2022.2049245
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Objective: To explore the pregnancy outcomes of women who couldn't obtain effective results from noninvasive prenatal testing (NIPT) and examine the factors leading to test failure. Methods: From April 2017 to December 2019, 120, 041 pregnant women enrolled for voluntary NIPT. The case group comprised of 274 (274/120, 041) women who failed to obtain effective NIPT results, and the control group ( n = 540) was from the same population who obtained effective NIPT results and matched by age at a 1:2 ratio. Abnormal pregnancy rates between the two groups were analyzed using Chi-square analysis. NIPT failure risk factors were analyzed using logistic regression analysis. Results: Logistic regression analysis showed that increased maternal age (OR = 0.988; 95% CI = 0.982–0.994), increased pregnancy age (OR = 0.989; 95%CI = 0.988–0.991), and decreased cell-free fetal DNA concentration (OR = 1.050; 95%CI = 1.043–1.058) were independent risk factors for NIPT failure. Fifteen cases showed fetus loss in cases of NIPT failure. There was a significant difference in abnormal pregnancy rate between the NIPT success and failure groups (χ2 = 50.943, P < 0.05). Expert commentary: The specific interventions, guidance, and precautions are needed for pregnant women who have no effective NIPT results.