Development and validation of a LC-PDA method for methylphenidate analysis in sewage. Issue 1 (29th March 2022)

• Record Type: Journal Article
• Authors: Paixão, Maiara C. S.; Nardi, Jessica; Bertol, Charise D.; Freddo, Natália; Vieira, Bruna F.; Rosano, Vitoria A.; Friedrich, Maria T.; Rossato-Grando, Luciana G.
• Is Part Of: Journal of environmental science and health. Volume 57:Issue 1(2022)
• Page Start: 28
• Page End: 32
• Publication Date: 2022-03-29
• Subjects: Methylphenidate -- emerging pollutants -- wastewater -- method validation -- HPLC -- PDA -- environmental contamination; Environmental engineering -- Periodicals; Environmental sciences -- Periodicals; Ecology -- periodicals; Hazardous Substances -- periodicals; 628
• DOI: 10.1080/10934529.2021.2020513
• Languages: English
• ISSNs: 1093-4529

Abstract

Abstract: Methylphenidate (MPH) is an important emerging pollutant found in effluents and wastewater. Thus, we aimed to develop and validate a method for detection and quantitation of MPH residues in sewage through high performance liquid chromatography coupled with photodiode array detector (LC-PDA). Here we describe a selective, accurate, precise, and valid method for determination of MPH in sewage with a total running time of 10 min, with limits of detection and quantification of 0.27 and 0.92 µg/mL, respectively. MPH retention peak was observed at 5 min. The method was applied to MPH analysis in a sewage sample pretreated with solid phase extraction, obtaining a result of 2.8 µg/L of MPH. Thus, the developed method can be considered feasible to be applied to MPH residual contamination analysis in sewage using a widely available apparatus.