Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination. (7th August 2021)

• Record Type: Journal Article
• Authors: North, Crystal M; Barczak, Amy; Goldstein, Robert H; Healy, Brian C; Finkelstein, Dianne M; Ding, Delaney D; Kim, Andy; Boucau, Julie; Shaw, Bennett; Gilbert, Rebecca F; Vyas, Tammy; Reynolds, Zahra; Siddle, Katherine J; MacInnis, Bronwyn L; Regan, James; Flynn, James P; Choudhary, Manish C; Vyas, Jatin M; Laskowski, Karl; Dighe, Anand S; Lemieux, Jacob E; Li, Jonathan Z; Baden, Lindsey R; Siedner, Mark J; Woolley, Ann E; Sacks, Chana A
• Is Part Of: Clinical infectious diseases. Volume 74:Number 7(2022)
• Page Start: 1275
• Page End: 1278
• Publication Date: 2021-08-07
• Subjects: COVID -- SARS-CoV-2 -- pandemic -- incidence -- vaccine; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab643
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were observed following vaccination, the higher cycle thresholds, repeat negative tests, and inability to culture virus raise questions about their clinical significance.