A warfarin-antibiotic drug-drug interaction: a podiatric surgical case report. (2nd April 2022)

• Record Type: Journal Article
• Authors: Feeney, Sally; Rees, Sharon; Modha, Ravi Krishān
• Is Part Of: Journal of prescribing practice. Volume 4:Number 4(2022)
• Page Start: 156
• Page End: 159
• Publication Date: 2022-04-02
• Subjects: drug-drug interaction -- warfarin -- post-surgical infection; Drugs -- Prescribing -- Periodicals; Nurse practitioners -- Periodicals; 615.1
• DOI: 10.12968/jprp.2022.4.4.156
• Languages: English
• ISSNs: 2631-8385

Abstract

Abstract : Several groups of antibiotics are known to interact with warfarin, presenting a challenge to the prescriber trying to manage underlying clinical infection, whilst mitigating the risk of coagulopathy. The authors present a case report of a 64-year old warfarinised patient who underwent forefoot surgery and developed a subsequent post-operative infection with combinations of antibiotics, leading to excessive anticoagulation and an adverse drug event. From reviewing both local and national guidance, careful monitoring is mandatory, dosing adjustments and pre-emptive dose reduction might also be needed. Consultation within the wider multi-disciplinary network will be central to decision making and implementing safety netting measures.