Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives. Issue 8 (15th April 2022)

• Record Type: Journal Article
• Authors: Debette, Stéphanie; Markus, Hugh S.
• Is Part Of: Circulation research. Volume 130:Issue 8(2022)
• Page Start: 1095
• Page End: 1111
• Publication Date: 2022-04-15
• Subjects: cause of death -- genome-wide association studies -- genomics -- gray matter -- small vessel disease -- stroke -- white matter; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.122.319950
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Stroke is the second leading cause of death worldwide and a complex, heterogeneous condition. In this review, we provide an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting recent insight into the continuum between these. We describe how, in recent years, large-scale genome-wide association studies have enabled major progress in deciphering the genetic basis for stroke and its subtypes, although more research is needed to interpret these findings. We cover the potential of stroke genetics to reveal novel pathophysiological processes underlying stroke, to accelerate the discovery of new therapeutic approaches, and to identify individuals in the population who are at high risk of stroke and could be targeted for tailored preventative interventions.