Control of host mitochondria by bacterial pathogens. Issue 5 (May 2022)

• Record Type: Journal Article
• Authors: Marchi, Saverio; Morroni, Gianluca; Pinton, Paolo; Galluzzi, Lorenzo
• Is Part Of: Trends in microbiology. Volume 30:Issue 5(2022)
• Page Start: 452
• Page End: 465
• Publication Date: 2022-05
• Subjects: autophagy -- Listeria monocytogenes -- mitochondria-associated ER membranes -- Mycobacterium tuberculosis -- oxidative phosphorylation -- regulated cell death; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2021.09.010
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca 2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells. Highlights: Mitochondria, the evolutionary successors of an ancient endosymbiotic prokaryote, occupy a central position in the biology of modern eukaryotic cells. Numerous pathogenic bacteria have evolved strategies to subvert the mitochondrial functions of host cells in support of proliferation and dissemination. The control of metabolism, Ca 2+ fluxes, autophagy, and regulated cell death at mitochondrial level provides invading pathogens with a considerable evolutionary advantage.