Comprehensive evaluation on cancer of unknown primary site and how we managed it: A case report. (April 2022)

• Record Type: Journal Article
• Authors: Yulian, Erwin Danil; Hwei, Lie Rebecca Yen; Tambun, Renaningtyas; Siswoyo, Alvita Dewi; Ham, Maria Fransisca; Suroyo, Indrati
• Is Part Of: International journal of surgery case reports. Volume 93(2022)
• Publication Date: 2022-04
• Subjects: CUP cancer of unknown primary site -- FNAB fine needle aspiration biopsy -- MRI magnetic resonance imaging -- MCCAs molecular cancer classifier assays; Cancer of unknown primary site -- Squamous cell carcinoma -- Metastatic cancer -- Radical neck dissection -- Axilla dissection -- Trimodal modalities; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2022.106954
• Languages: English
• ISSNs: 2210-2612

Abstract

Abstract: Introduction and importance: Cancer of unknown primary site (CUP) is metastatic cancer without primary tumor found from comprehensive medical history, physical examination, and regular laboratory examination. Eighty percent of CUP include unfavorable groups with 3 to 6 months of median survival despite chemotherapy treatment. Case presentation: A 52-year-old male was presented with a chief complaint of a recurrent lump in the neck and axilla. After comprehensive examinations over three years, the primary site of the metastatic tumor could not be found. Therefore, this patient was diagnosed with cancer of an unknown primary site. Clinical discussion: In patient with CUP, more precise therapy can only begin when the exact form of cancer is identified. However, the delay in diagnosis would worsen the patient's condition, as treatment measures cannot be implemented. Conclusion: Trimodal modalities including surgery, chemotherapy, and radiotherapy are suitable for CUP with squamous cell carcinoma proven in immunohistochemistry evaluation. Highlights: Precise therapy for patients with CUP can only begin when the exact form of cancer is identified. Although PET/CT is suitable to assess the complete body state for CUP, other radiological and histopathology modalities are needed to confirm the diagnosis. Trimodal modalities including surgery, chemotherapy, and radiotherapy are required for CUP with squamous cell carcinoma.