Protein-polysaccharide interactions for the fabrication of bioactive-loaded nanocarriers: Chemical conjugates and physical complexes. (April 2022)

• Record Type: Journal Article
• Authors: Falsafi, Seid Reza; Rostamabadi, Hadis; Samborska, Katarzyna; Mirarab, Saeed; Rashidinejhad, Ali; Jafari, Seid Mahdi
• Is Part Of: Pharmacological research. Volume 178(2022)
• Publication Date: 2022-04
• Subjects: Curcumin (PubChem CID: 969516) -- Chitosan (PubChem CID: 71853) -- Pectin (PubChem CID: 441476) -- Casein (PubChem CID: 73995022) -- β-carotene (PubChem CID: 5280489) -- Alginate (PubChem CID: 131704328) -- Maltodextrins (PubChem CID: 68229136) -- gum Arabic (PubChem CID: 91333377) -- Genipin (PubChem CID: 442424) -- Carrageenan (PubChem CID: 78126884); Millard conjugation -- Electrostatic complexation -- Proteins -- Polysaccharides -- Bioactives -- Delivery systems; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2022.106164
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: As unique biopolymeric architectures, covalently and electrostatically protein-polysaccharide (PRO-POL) systems can be utilized for bioactive delivery by virtue of their featured structures and unique physicochemical attributes. PRO-POL systems (i. e, microscopic /nano-dimensional multipolymer particles, molecularly conjugated vehicles, hydrogels/nanogels/oleogels/emulgels, biofunctional films, multilayer emulsion-based delivery systems, particles for Pickering emulsions, and multilayer coated liposomal nanocarriers) possess a number of outstanding attributes, like biocompatibility, biodegradability, and bioavailability with low toxicity that qualify them as powerful agents for the delivery of different bioactive ingredients. To take benefits from these systems, an in-depth understanding of the chemical conjugates and physical complexes of the PRO-POL systems is crucial. In this review, we offer a comprehensive study concerning the unique properties of covalently/electrostatically PRO-POL systems and introduce emerging platforms to fabricate relevant nanocarriers for encapsulation of bioactive components along with a subsequent sustained/controlled release. Graphical Abstract: ga1