Associations between cognitive impairment and cortical thickness alterations in patients with euthymic and depressive bipolar disorder. (June 2022)

• Record Type: Journal Article
• Authors: Kang, Youbin; Kang, Wooyoung; Han, Kyu-Man; Tae, Woo-Suk; Ham, Byung-Joo
• Is Part Of: Psychiatry research. Volume 322(2022)
• Publication Date: 2022-06
• Subjects: Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2022.111462
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: Cognitive functions and cortical thickness of the whole brain of patients with euthymic and depressive BP were compared. Reduced thickness was observed in diverse frontal regions in the euthymic BP, which were positively correlated with cognitive function test scores. The depressive BP group demonstrated thickening in the superior occipital gyri and occipitotemporal gyrus, suggesting a cortical dysfunction-related compensation mechanism. Illness duration might play a more important role than expected in cognitive functions as the residing executive discomfort remained in euthymic BP.