Comparative evaluation of the humoral immune interaction when BCG and conjugated meningococcal vaccines combined or co-administrated in mice. (May 2022)

• Record Type: Journal Article
• Authors: Abbas, Anas M.; Rashed, Mohamed E.; El-Gebaly, Eman; AbdelAllah, Nourhan H.; Gaber, Yasser
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 84(2022)
• Publication Date: 2022-05
• Subjects: BCG -- Conjugated meningococcal -- Vaccine -- Combined -- Co-administration; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2022.101778
• Languages: English
• ISSNs: 0147-9571

Abstract

Abstract: BCG and conjugated meningococcal vaccines (cMen) are part of the recommended immunization program for young children (<5 years) in many countries all over the world. However, there was no immunogenicity supportive data to assess the effect of BCG and cMen vaccines when combined or co-administrated. Therefore, we sought to evaluate the antibody response in mice groups when BCG and cMen vaccines were whether in combination, co-administration simultaneously or administration with a 14-day gap interval. Our results showed that cMen either combined with BCG vaccine or co-administrated had a significant negative humoral immune effect on each other. This negative impact was observed also when there were 2 weeks between their administration regardless of the vaccination order. Therefore, our results support that it is preferable to separate the two vaccination for > 14 days at least. But additional studies are needed to explore the cellular-mediate response of the immune intervention as well. Highlights: Mice groups were injected with BCG vaccine and conjugated meningococcal vaccines. The vaccines were administrated combined, co-administrated or 14 days apart. Antibodies were assessed by ELISA after 6 weeks from the 1st dose of each vaccine. BCG with conjugate meningococcal vaccine negatively impact their antibodies levels.