Nonstereoselective behavior of novel chiral organophosphorus pesticide Dufulin in cherry radish by different absorption methods. (15th June 2022)

• Record Type: Journal Article
• Authors: Zheng, Ruonan; Shao, Siyao; Zhang, Sufen; Yu, Zhiyang; Zhang, Weiwei; Wu, Tao; Zhou, Xin; Ye, Qingfu
• Is Part Of: Environmental pollution. Volume 303(2022)
• Publication Date: 2022-06-15
• Subjects: Dufulin -- Stereoselective -- Translocation -- Uptake -- Accumulation; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2022.119100
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Dufulin is a biologically derived antiviral agent chemically synthesized by α-phosphoramidate in sheep and is effective against viral diseases in plants such as tobacco, rice, cucumber and tomato. However, the environmental behaviors and fate of Dufulin under different cultivation systems remain unknown. This study investigates the absorption, translocation and accumulation of 14 C-Dufulin stereoisomers introduced by pesticide leaf daubing and by mixing the pesticide with soil in different tissues of cherry radish. We particularly focused on whether the behaviors of Dufulin enantiomers in plants were stereoselective. In the leaf uptake experiments, S-Dufulin and R-Dufulin were transported both up and down, while more than 93% of the pesticide remained in the labeled leaves. During the radicular absorption experiments, both enantiomers of Dufulin were taken up by radish roots and moved to the upper part of the plant, while less than 0.2% Dufulin was absorbed from the soil. Hence, it was easier for Dufulin to enter plants through the leaf surface than through the roots. However, we found in this trial that the stereoisomers of Dufulin underwent nonstereoselective absorption and translocation, which implies that rac-Dufulin and its metabolites should be a major research priority. Overall, our results provide a relatively accurate prediction of the risk assessment of Dufulin, which will help guide its rational use in the environment as well as ensure eco-environmental safety and human health. Graphical abstract: Image 1 Highlights: Most of the Dufulin enantiomers absorbed by leaves remained in the labeled leaf. Only a small amount of Dufulin enantiomers transported to other tissues. Dufulin enantiomers absorbed into the plant through the roots were extremely few. Non-stereoselectivity was found in distribution either absorbed by leaves or roots.