Forensic features and genetic structure revealed by 47 individual identification InDels in the Shaanxi Han population. (May 2022)

• Record Type: Journal Article
• Authors: Xu, Hui; Zhao, Congying; Lan, Qiong; Li, Shuxin; Liu, Yanfang; Mei, Shuyan; Fang, Yating; Zhu, Bofeng
• Is Part Of: Legal medicine. Volume 56(2022)
• Publication Date: 2022-05
• Subjects: Insertion/deletion polymorphism -- Population genetics -- Shaanxi Han population; Medical jurisprudence -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Medical jurisprudence; Periodicals; 614.1
• DOI: 10.1016/j.legalmed.2022.102030
• Languages: English
• ISSNs: 1344-6223

Abstract

Highlights: The genetic polymorphisms and forensic parameters of 47 InDels were investigated in the Shaanxi Han population. The interpopulation comparisons and population genetic structure analyses of 47 InDels were performed in the 44 worldwide populations. The AGCU InDel 50 Kit was of high forensic efficiency in the Shaanxi Han population. Abstract: Insertion/deletion (InDel) polymorphism genetic marker is a powerful and prospective tool for human identification and population genetic studies. Considering that the genetic polymorphisms and ethnic background of the Shaanxi Han population have not been fully explored to this day, herein, the novel developed AGCU InDel 50 kit which included 47 autosomal InDels was applied in the 556 unrelated healthy Han individuals from Shaanxi province for the first time. There were no significant deviations from Hardy–Weinberg equilibrium and linkage equilibrium at the 47 InDels after Bonferroni correction. In the Shaanxi Han population, the values of combined discrimination power and cumulative exclusion probability for the 47 InDels were 0.999999999999999999891 and 0.99966, respectively. Furthermore, the interpopulation comparisons and population genetic structure analyses based on the 47 InDels were performed among the Shaanxi Han population and 43 reference populations, and the results showed that the Shaanxi Han population exhibited similar genetic structure and closer genetic affinities with the East Asian populations.