Micellar‐emphasized simultaneous determination of ivabradine hydrochloride and felodipine using synchronous spectrofluorimetry. (9th February 2022)

• Record Type: Journal Article
• Authors: Yosrey, Eman; Elmansi, Heba; Sheribah, Zeinab A.; Metwally, Mohamed El‐Sayed
• Is Part Of: Luminescence. Volume 37:Number 4(2022)
• Page Start: 569
• Page End: 576
• Publication Date: 2022-02-09
• Subjects: felodipine -- green micellar -- ivabradine hydrochloride; Luminescence -- Periodicals; Bioluminescence -- Periodicals; Chemiluminescence -- Periodicals; Luminescence -- Periodicals; 535.35
• DOI: 10.1002/bio.4187
• Languages: English
• ISSNs: 1522-7235

Abstract

Abstract: A sensitive and green micellar spectrofluorimetric approach was applied for the simultaneous estimation of ivabradine hydrochloride (IVB) and felodipine (FLD) in the ng/ml concentration range. The approach depended on measuring the first derivative synchronous peak amplitude ( 1 D) of both drugs at ∆λ = 60 nm in a Tween‐80 micellar system. The method was rectilinear alongside the concentration ranges 0.02–0.4 μg/ml and 0.05–1.0 μg/ml at 269.5 nm and 378.5 nm for IVB and FLD, respectively. The proposed method was validated by following the International Council for Harmonization guidelines. The method was successfully applied without interference for laboratory‐prepared synthetic mixtures, single pharmaceutical preparations, and within spiked biological fluids with acceptable percentage recoveries. A comparison of the performance of the suggested method with other methods, showed no discrepancy. The method's ecofriendly property evaluated using three different tools, confirming an excellent green method. Abstract : Green evaluation of the micellar synchronized determination of FLD and IVB using GAPI and NEMI.