Hydrogenated Oxide Material for Self‐Targeting and Automatic‐Degrading Photothermal Tumor Therapy in the NIR‐II Bio‐Window. (19th December 2021)

• Record Type: Journal Article
• Authors: Zhu, Qing; Jiang, Wei; Ye, Ke; Jin, Shunru; Dong, Wang; Liu, Songde; Zhang, Guozhen; Tian, Chao; Luo, Yi; Wang, Yucai; Jiang, Jun
• Is Part Of: Advanced functional materials. Volume 32:Number 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-19
• Subjects: hydrogenated metal oxide -- photothermal agent -- pH‐responsive degradation -- second near‐infrared biowindow -- tumor hyperthermia; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202110881
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Developing photothermal agents (PTAs) for tumor therapy has three prerequisites: selectively targeting tumors, efficiently converting near‐infrared (NIR) photoenergy to heat, and degrading after the cure. These make up a combination rarely found in one material. Here a metal‐acid treatment is reported to hydrogenate metal oxide, bestowing the produced H x MoO3 with metal‐like electronic structure which enables harvesting NIR‐II light (1000−1350 nm wavelength). Importantly, created by putting acid protons into oxide, the H x MoO3 nanomaterial can resist attacking from protons in acids but is vulnerable to hydroxyl ions in alkaline. After entering biological organism, H x MoO3 PTAs persist long in acidic tumor microenvironment (TME, extracellular pH 6.5–6.9) while degrade quickly under the normal physiological environment (pH 7.2−7.4), naturally causing tumor‐selective accumulation. Under 1064 nm NIR‐II illumination, the H x MoO3 achieves a high photothermal conversion efficiency of 60.9%, leading to a high tumor inhibition rate of ≈97.25%. Such a novel PTAs integrates merits of metal and oxide, opening a door of smart photothermal therapy with self‐adaptive tumor‐accumulation and automatic degradation after tumor hyperthermia. Abstract : Hydrogenated metal oxides are prepared by metal‐acid treatment, resulting in pH‐selective materials that are stable in acids but vulnerable in alkaline solutions. It led to a novel type of smart photothermal agents that target only onto tumors with acidic condition and degrade in healthy cells. They not only retain the good biocompatibility and low cytotoxicity of their parent oxide material, but also combine merits of metals with highly efficient photothermal conversion and thermal conductivity, serving as excellent photothermal reagents working in the near infrared‐Ⅱ biowindow.