In Vitro Anticancer Ability of Nano Fluorescent 111In‐MIL‐68/PEG‐FA on Hela Cells. Issue 19 (8th March 2022)

• Record Type: Journal Article
• Authors: Liang, Ranxi; Liao, Zhonghui; Li, Feize; Ma, Huan; Liu, Weihao; Chen, Xijian; Lan, Tu; Yang, Yuanyou; Liao, Jiali; Yang, Jijun; Liu, Ning
• Is Part Of: Chemistry. Volume 28:Issue 19(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-08
• Subjects: antitumor -- fluorescence imaging -- metal-organic frameworks -- radiolabeling; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202104589
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: In past decades, nanoscale metal‐organic frameworks (NMOFs) have drawn more and more attention in multimodal imaging and targeting therapy of various malignant cancers. Here, we proposed to dope 111 In into fluorescent In‐based NMOFs (In‐MIL‐68‐NH2 ), with an attempt to prepare a new nanomedicine with great anticancer potential. As a proof of concept, the obtained NMOF (In‐MIL‐68/PEG‐FA) with targeting motifs is able to act as a fluorescent probe to achieve Hela cell imaging. Moreover, the Auger electron emitter 111 In built in corresponding radioactive NMOF ( 111 In‐MIL‐68/PEG‐FA) can bring clear damage to cancer cells, leading to a high cell killing rate of 59.3 % within 48 h. In addition, the cell cycle presented a significant dose‐dependent G2/M inhibiting mode, which indicates that 111 In‐MIL‐68/PEG‐FA has the ability to facilitate the cancer cells to enter apoptotic program. This work demonstrated the potential of 111 In‐labelled NMOFs in specific killings of cancer cells, providing a new approach to develop nanomedicines with theranostic function. Abstract : A new type of nano fluorescent 111 In‐MOF with built‐in Auger electron emitter ( 111 In) is elaborately designed. The in vitro evaluations demonstrate that the obtained radioactive nanomedicine can specifically target Hela cells, and effectively inhibit the growth of cancer cells. Furthermore, the cell cycle distribution showed a dose‐dependent G2/M arrest mode, also indicating that the obtained 111 In‐MOF is able to promote the cells to enter apoptotic program.