Extruded poly (glycerol sebacate) and polyglycolic acid vascular graft forms a neoartery. (27th January 2022)

• Record Type: Journal Article
• Authors: Fukunishi, Takuma; Lui, Cecillia; Ong, Chin Siang; Dunn, Tyler; Xu, Shanxiu; Smoot, Carissa; Smalley, Ryan; Harris, Jeremy; Gabriele, Peter; Santhanam, Lakshmi; Lu, Steven; Hibino, Narutoshi
• Is Part Of: Journal of tissue engineering and regenerative medicine. Volume 16:Number 4(2022)
• Page Start: 346
• Page End: 354
• Publication Date: 2022-01-27
• Subjects: neoartery -- polyglycolic acid -- poly glycerol sebacate -- rapidly degrading -- tissue engineered vascular graft; Tissue engineering -- Periodicals; Regeneration (Biology) -- Periodicals; 610.28
• DOI: 10.1002/term.3282
• Languages: English
• ISSNs: 1932-6254

Abstract

Abstract: In the ongoing search for the optimal biomaterial for tissue engineered vascular grafts (TEVGs), poly (glycerol sebacate) (PGS) has emerged as a new potential candidate. We have utilized a novel method to create unique, pore‐free, extruded PGS grafts with and without a supportive exterior layer of polyglycolic acid (PGA). The 1 mm diameter by 5 mm length TEVGs were implanted in a rat model of infrarenal abdominal aorta interposition grafting. Three months after implantation, TEVGs comprised of extruded PGS with an external PGA braid demonstrated a patency rate of 9/10 (90%) with no signs of dilatation, dehiscence, or rupture. The PGS/PGA graft was remodeled into a neoartery with complete endothelialization of the neoartery lumen and formation of smooth muscle actinin multilayers as demonstrated via immunohistochemistry. Formation and maturation of extracellular matrix material were also observed, with amounts of elastin and collagen comparable to native rat aorta. No significant host inflammatory response was observed. These findings suggest the combination of an extruded PGS tube with an external reinforcing PGA braid is a promising material for small diameter TEVGs.