Gift bags from the sentinel cells of the immune system: The diverse role of dendritic cell‐derived extracellular vesicles. Issue 4 (26th October 2021)

• Record Type: Journal Article
• Authors: Hodge, Amy L.; Baxter, Amy A.; Poon, Ivan K. H.
• Is Part Of: Journal of leukocyte biology. Volume 111:Issue 4(2022)
• Page Start: 903
• Page End: 920
• Publication Date: 2021-10-26
• Subjects: antigen presentation -- apoptosis -- dendritic cells -- exosomes -- extracellular vesicles -- immunomodulation -- immunotherapy -- infection -- intercellular communication -- vaccine; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.3RU1220-801R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Dendritic cells (DCs) are professional APCs of the immune system that continuously sample their environment and function to stimulate an adaptive immune response by initiating Ag‐specific immunity or tolerance. Extracellular vesicles (EVs), small membrane‐bound structures, are released from DCs and have been discovered to harbor functional peptide‐MHC complexes, T cell costimulatory molecules, and other molecules essential for Ag presentation, immune cell regulation, and stimulating immune responses. As such, DC‐derived EVs are being explored as potential immunotherapeutic agents. DC‐derived EVs have also been implicated to function as a trafficking mechanism of infectious particles aiding viral propagation. This review will explore the unique features that enable DC‐derived EVs to regulate immune responses and interact with recipient cells, their roles within Ag‐presentation and disease settings, as well as speculating on a potential immunological role of apoptotic DC‐derived EVs. Graphical Abstract: Describes the functions of dendritic cell‐derived extracellular vesicles in the context of antigen presentation, infection, cell death and immunotherapy.