Very rare near‐haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR‐T therapy in 19‐year‐old male patient. Issue 3 (3rd March 2022)

• Record Type: Journal Article
• Authors: Arpas, Tomas; Jelinkova, Hana; Hrabovsky, Stepan; Orsulova, Martina; Vrzalova, Zuzana; Navrkalova, Veronika; Brhelova, Eva; Bryjova, Lenka; Bulikova, Alena; Ondrouskova, Eva; Sejnohova, Marketa; Folber, Frantisek; Sedová, Petra; Mayer, Jiri; Pospisilova, Sarka; Jarosova, Marie; Doubek, Michael
• Is Part Of: Clinical case reports. Volume 10:Issue 3(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-03
• Subjects: acute lymphoblastic leukemia -- blinatumomab -- CAR‐T therapy -- inotuzumab ozogamicin -- near‐haploid; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.5545
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: Near‐haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR‐T therapy. Abstract : A thorough cytogenetic analysis is necessary in all cases of acute lymphoblastic leukemia, as it can reveal subtypes of the disease with a significantly different prognosis.