Cellular Nanosponges for Biological Neutralization. Issue 13 (11th February 2022)

• Record Type: Journal Article
• Authors: Wang, Shuyan; Wang, Dan; Duan, Yaou; Zhou, Zhidong; Gao, Weiwei; Zhang, Liangfang
• Is Part Of: Advanced materials. Volume 34:Issue 13(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-11
• Subjects: cell‐membrane‐coated nanoparticle -- countermeasures -- detoxification -- nanomedicine -- nanotechnology; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202107719
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Biological neutralization represents a general strategy that deploys therapeutic agents to bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent them from causing the diseases. Here, a comprehensive review of using cell‐membrane‐coated nanoparticles, namely "cellular nanosponges, " as host decoys for a wide range of biological neutralization applications is provided. Compared to traditional neutralization strategies, the cellular nanosponges stand out by mimicking susceptible host cells rather than accommodating the structures of the causative agents for the design of therapeutics. As all pathological agents must interact with host cells for bioactivity, nanosponges bypass the diversity of these agents and create function‐driven and broad‐spectrum neutralization solutions. The review focuses on the recent progress of using this new nanomedicine platform for neutralization against five primary pathological agents, including bacterial toxins, chemical toxicants, inflammatory cytokines, pathological antibodies, and viruses. Existing studies have established cellular nanosponges as versatile tools for biological neutralization. A thorough review of the cellular nanosponge technology is expected to inspire more refined cellular nanosponge designs and unique neutralization applications to address unsolved medical problems. Abstract : The recent development of cell‐membrane‐coated nanoparticles, namely cellular nanosponges, as host cell decoys for biological neutralization applications is reviewed, including their use to neutralize bacterial toxins, chemical toxicants, inflammatory cytokines, pathological antibodies, and viruses. For each area, the design of different cellular nanosponges and their corresponding neutralization functions are discussed.