Tumor microenvironment-responsive size-switchable drug delivery nanosystems. (4th March 2022)

• Record Type: Journal Article
• Authors: Hu, Yue; Gao, Shan; Khan, Abdur Rauf; Yang, Xiaoye; Ji, Jianbo; Xi, Yanwei; Zhai, Guangxi
• Is Part Of: Expert opinion on drug delivery. Volume 19:Number 3(2022)
• Page Start: 221
• Page End: 234
• Publication Date: 2022-03-04
• Subjects: Nano-drug delivery systems -- particle size -- size-switchable -- tumor microenvironment; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2022.2042512
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Compared with ordinary chemotherapeutic drugs, the variable-size nanoparticles (NPs) have better therapeutic effects and fewer side effects. Areas covered: This review mainly summarizes the strategies used to construct smart, size-tunable nanocarriers based on characteristic factors of tumor microenvironment (TME) to dramatically increase the penetration and retention of drugs within tumors. Expert opinion: Nanosystems with changeable sizes based on the TME have been extensively studied in the past decade, and their permeability and retention have been greatly improved, making them a very promising treatment for tumors. Graphical abstract: uf0001