Comparing multi-attribute utility instruments: CP-6D, a Cerebral palsy specific instrument, vs AQoL-4D. (17th February 2022)

• Record Type: Journal Article
• Authors: Bahrampour, Mina; Downes, Martin; Scuffham, Paul a; Byrnes, Joshua
• Is Part Of: Expert review of pharmacoeconomics & outcomes research. Volume 22:Number 2(2022)
• Page Start: 217
• Page End: 224
• Publication Date: 2022-02-17
• Subjects: Utility -- validity -- CP-6D -- AQoL-4D -- health-related quality of life -- Cerebral palsy -- preference-based measure; Pharmacology -- Economic aspects -- Periodicals; 338.47615105
• DOI: 10.1080/14737167.2021.1909477
• Languages: English
• ISSNs: 1473-7167

Abstract

ABSTRACT: Background: Economic-evaluations of Cerebral palsy (CP) were based on utility estimates of health-related quality of life (HRQoL) from generic multi-attribute utility instruments (MAUIs). However, generic instruments had limited use as they could not capture some of the important aspects of living with CP. The Cerebral palsy 6 Dimension (CP-6D) is a disease specific MAUI. In this study, we compared the results of CP-6D with the Assessment of Quality of Life (AQoL-4D), a generic MAUI, and tested the criterion validity of the CP-6D in the general population. Methods: An online survey of the Australian general population (n = 2002), who completed both the AQoL-4D and CP-6D MAUIs, was conducted. Validity was assessed from the correlations between the domains, items and instruments. ANOVA and t-tests were used to assess the instrument's discrimination in different social demographic categories. Result: There was a moderate correlation between the instruments (0.64). Differences in socio-demographic characteristics showed a medium effect size ( p < 0.001) in both instruments and had a similar effect on utility weights in both instruments. Although the CP-6D was more sensitive to changes in income and education. Conclusions: Our results suggest that CP-6D and AQoL-4D were measuring a similar underlying construct. Both instruments responded similarly to socio-demographic differences.