Anti-mycobacterial natural products and mechanisms of action. Issue 1 (6th July 2021)

• Record Type: Journal Article
• Authors: Han, Jianying; Liu, Xueting; Zhang, Lixin; Quinn, Ronald J.; Feng, Yunjiang
• Is Part Of: Natural product reports. Volume 39:Issue 1(2022)
• Page Start: 77
• Page End: 89
• Publication Date: 2021-07-06
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/d1np00011j
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : This review summarises the molecular targets of 53 anti-TB natural products and highlights the compounds with novel targets and activity against drug-resistant TB. Abstract : Covering: up to June, 2020 Tuberculosis (TB) continues to be a major disease with high mortality and morbidity globally. Drug resistance and long duration of treatment make antituberculosis drug discovery more challenging. In this review, we summarize recent advances on anti-TB natural products (NPs) and their potential molecular targets in cell wall synthesis, protein production, energy generation, nucleic acid synthesis and other emerging areas. We highlight compounds with activity against drug-resistant TB, and reveal several novel targets including Mtb biotin synthase, ATP synthase, 1, 4-dihydroxy-2-naphthoate prenyltransferase and biofilms. These anti-TB NPs and their targets could facilitate target-based screening and accelerate TB drug discovery.