Down-regulation of CatSper 1 and CatSper 2 genes by methamphetamine. (2nd January 2022)

• Record Type: Journal Article
• Authors: Mansouri, Somaieh; Jalali, Mehdi; Nikravesh, Mohammad Reza; Soukhtanloo, Mohammad
• Is Part Of: Toxin reviews. Volume 41:Number 1(2022)
• Page Start: 261
• Page End: 267
• Publication Date: 2022-01-02
• Subjects: Methamphetamine -- CatSper -- fertility -- mice -- spermatozoa; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2020.1868007
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: Methamphetamine (METH) is a strong central nervous system stimulant that has toxic effects on the reproductive system. The aim of this study was to evaluate changes in gene and protein expression levels of CatSper1, 2, and oxidative stress after exposure to METH in the testis of mice. The mRNA and protein expression levels of CatSper1, 2 decreased in the experimental groups. The administration of METH caused a decrease of SOD and CAT activities and an increase in the MDA level. METH damaged the male reproductive system via the oxidative stress pathway and by reduction of CatSper1, 2 genes and protein expression. Mini-abstract: Administration of METH damaged the male reproductive system via the oxidative stress pathway and reduction of CatSper1, 2 genes and protein expression.