Synthesis, characterization, superoxide dismutase, and antimicrobial activities of Co (II) complexes with Schiff base ligand and their hybrid proteins. (17th January 2022)

• Record Type: Journal Article
• Authors: Mo, Dan; Song, Xun; Wu, Jiri; Jaiswal, Yogini; Guan, Yifu; Zhang, Yuzhen; Shen, Yunjun; Bian, Hedong
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-17
• Subjects: antimicrobial activity -- BSA -- hybrid protein -- Schiff base complex -- SOD activity; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6587
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract: Metal complexes have been reported to possess excellent free radical scavenging and antimicrobial properties. In the present study, seven linear trinuclear complexes were synthesized based on bis Schiff base ligand and complexes 1, 3 –7 are reported for the first time. Their structure was characterized by IR spectroscopy and single crystal diffraction. BSA was used as carrier to hybridize the synthesized complexes to construct hybrid proteins. The interaction between metal complex and BSA was studied by UV–Vis spectrophotometry and fluorescence spectroscopy. Static quenching was the main mechanism identified for the interaction between metal complex and BSA. In the superoxide dismutase (SOD) activity test, IC50 values of complexes and hybrid proteins range between 2.89 and 26.53 μM, with hybrid proteins demonstrating a stronger activity than the complexes. Among all the complexes studied, complex 5 exhibited the strongest inhibition against Candida albicans (MIC 12.5 μg ml −1 ) and Cryptococcus neoformans (MIC 6.5 μg ml −1 ). Abstract : Seven linear trinuclear Co (II) complexes were synthesized and characterized based on bis Schiff base ligand. Hybrid proteins were constructed by use of metal complexes and bovine serum albumin. The bioactivity evaluation showed that the complexes and their hybrid proteins possess significant SOD or antimicrobial activity.