Synthesis of carbon-11 radiolabelled transition metal complexes using 11C-dithiocarbamates. Issue 13 (16th March 2022)

• Record Type: Journal Article
• Authors: Cesarec, Sara; Edgar, Fraser; Lai, Titan; Plisson, Christophe; White, Andrew J. P.; Miller, Philip W.
• Is Part Of: Dalton transactions. Volume 51:Issue 13(2022)
• Page Start: 5004
• Page End: 5008
• Publication Date: 2022-03-16
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d2dt00266c
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Fast and efficient radiolabelling using 11 C-dithiocarbamate ligands to generate a range of novel 11 C-labelled transition metal complexes in high radiochemical yields. Abstract : A novel radiolabelling method exploiting 11 C-dithiocarbamate ligands has been used to generate 11 C-labelled Au(i ), Au(iii ), Pd(ii ) and Pt(ii ) complexes in high radiochemical yields (71–99%). Labelled complexes were prepared in a rapid one-pot procedure via the substitution reaction of 11 C-dithiocarbamate ligands with appropriate transition metal chloride precursors.