Proximity-enhanced synthesis of DNA–peptide–DNA triblock molecules. Issue 25 (8th March 2022)
- Record Type:
- Journal Article
- Title:
- Proximity-enhanced synthesis of DNA–peptide–DNA triblock molecules. Issue 25 (8th March 2022)
- Main Title:
- Proximity-enhanced synthesis of DNA–peptide–DNA triblock molecules
- Authors:
- MacCulloch, Tara
Novacek, Alexandra
Stephanopoulos, Nicholas - Abstract:
- Abstract : We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Abstract : We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Our method relies on sequential bioorthogonal reactions, and partial hybridization of the second handle to the first. We demonstrate the synthesis of a protease-responsive DNA "latch" and a cyclic bioactive peptide using this method.
- Is Part Of:
- Chemical communications. Volume 58:Issue 25(2022)
- Journal:
- Chemical communications
- Issue:
- Volume 58:Issue 25(2022)
- Issue Display:
- Volume 58, Issue 25 (2022)
- Year:
- 2022
- Volume:
- 58
- Issue:
- 25
- Issue Sort Value:
- 2022-0058-0025-0000
- Page Start:
- 4044
- Page End:
- 4047
- Publication Date:
- 2022-03-08
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc04970d ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 21188.xml