Homochiral imidazolium-based dicarboxylate silver(i) compounds: synthesis, characterisation and antimicrobial properties. Issue 13 (16th March 2022)

• Record Type: Journal Article
• Authors: Carrasco, Carlos J.; Montilla, Francisco; Álvarez, Eleuterio; Galindo, Agustín; Pérez-Aranda, María; Pajuelo, Eloísa; Alcudia, Ana
• Is Part Of: Dalton transactions. Volume 51:Issue 13(2022)
• Page Start: 5061
• Page End: 5071
• Publication Date: 2022-03-16
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt04213k
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Ag(i ) complexes derived from chiral imidazolium-based dicarboxylate ligands have shown good antimicrobial activity toward Gram-negative bacteria. A chirality-antimicrobial tendency has been revealed. Abstract : Complexes [Ag(L R )], 2 (L R = 2, 2′-(imidazolium-1, 3-diyl)di(2- alkyl acetate)), were prepared by treatment of compounds HL R, 1, with Ag2 O. They were characterised by analytical, spectroscopic (IR, 1 H and 13 C NMR and polarimetry) and X-ray methods (2c, 2c′ and 2e ). In the solid state, these compounds are novel one-dimensional or two-dimensional coordination polymers in which silver(i ) cations are connected via the chiral [L R ] − anion with unprecedented coordination modes. The antimicrobial properties of these complexes were evaluated. 2a and 2b′ showed the best antimicrobial properties (minimal inhibitory concentrations and minimal bactericidal concentration) for Pseudomonas aeruginosa and Escherichia coli pathogens. Eutomers 2b′ and 2c′ showed slightly better antimicrobial properties than their respective enantiomers 2b and 2c .