Biodegradable MoOx@MB incorporated hydrogel as light-activated dressing for rapid and safe bacteria eradication and wound healing. Issue 15 (22nd March 2022)

• Record Type: Journal Article
• Authors: Wang, Yifan; Yao, Huiqin; Zu, Yan; Yin, Wenyan
• Is Part Of: RSC advances. Volume 12:Issue 15(2022)
• Page Start: 8862
• Page End: 8877
• Publication Date: 2022-03-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra00963c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A photoactivated MoO x @MB-hy hydrogel was constructed with synergistic photothermal–photodynamic therapy properties for enhanced ROS accumulation on a bacterial surface to rapidly eradicate bacteria and accelerate the healing of wounds infected by drug-resistant bacteria. Abstract : Wounds infected with drug-resistant bacteria are hard to treat, which remains a serious problem in clinical practice. An innovative strategy for treating wound infections is thus imperative. Herein, we describe the construction of a nanocomposite from biocompatible poly(vinyl alcohol) (PVA)/polyethylene glycol (PEG) hydrogel loaded biodegradable MoO x nanoparticles (NPs) and photosensitizer methylene blue (MB), denoted as MoO x @MB-hy. By incorporating MoO x @MB NPs, the nanocomposite hydrogel can act as a photoactivated wound dressing for near-infrared-II 1064 nm and 660 nm laser synergetic photothermal–photodynamic therapy (PTT–PDT). The key to PTT-induced heat becomes the most controllable release of MB from MoO x @MB-hy to produce more 1 O2 under 660 nm irradiation. Importantly, MoO x @MB-hy can consume glutathione (GSH) and trap bacteria nearer to the distance limit of ROS damage to achieve a self-migration-enhanced accumulation of reactive oxygen species (ROS), thereby conquering the intrinsic shortcomings of short diffusion distance and lifetime of ROS. Consequently, MoO x @MB-hy has high antibacterial efficiencies of 99.28% and 99.16% against Amp r E. coli and B. subtilis within 15 min. Moreover, the light-activated strategy can rapidly promote healing in wounds infected by drug-resistant bacteria. This work paves a way to design a novel nanocomposite hydrogel dressing for safe and highly-efficient antibacterial therapy.