Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022). Issue 9 (25th March 2022) - Yin, Yuan
Abstract : Small Extracellular Vesicles In colorectal cancer (CRC) tissues, tumor cell‐derived small extracellular vesicles (sEVs) miR‐21‐5p and miR‐200a synergistically induce macrophage M2 like polarization and PD‐L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8 + T cell activity and increased tumor growth. More details can be found in article number 202102620 by Shenglin Huang, Zhaohui Huang, and co‐workers.