Point-of-care COPD diagnostics: biomarkers, sampling, paper-based analytical devices, and perspectives. Issue 7 (3rd February 2022)

• Record Type: Journal Article
• Authors: He, Guozhen; Dong, Tao; Yang, Zhaochu; Branstad, Are; Huang, Lan; Jiang, Zhuangde
• Is Part Of: Analyst. Volume 147:Issue 7(2022)
• Page Start: 1273
• Page End: 1293
• Publication Date: 2022-02-03
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d1an01702k
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : COPD has become a major disease with great social and economic impacts. To enable point-of-care COPD diagnostics, paper-based analytical device is a promising candidate; however, it requires synergetic studies of biomarkers, biofluids, and sampling. Abstract : Chronic obstructive pulmonary disease (COPD) has become the third leading cause of global death. Insufficiency in early diagnosis and treatment of COPD, especially COPD exacerbations, leads to a tremendous economic burden and medical costs. A cost-effective and timely prevention requires decentralized point-of-care diagnostics at patients' residences at affordable prices. Advances in point-of-care (POC) diagnostics may offer new solutions to reduce medical expenditures by measuring salivary and blood biomarkers. Among them, paper-based analytical devices have been the most promising candidates due to their advantages of being affordable, biocompatible, disposable, scalable, and easy to modify. In this review, we present salivary and blood biomarkers related to COPD endotypes and exacerbations, summarize current technologies to collect human whole saliva and whole blood samples, evaluate state-of-the-art paper-based analytical devices that detect COPD biomarkers in saliva and blood, and discuss existing challenges with outlooks on future paper-based POC systems for COPD diagnosis and management.