Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and Challenges. (December 2021)

• Record Type: Journal Article
• Authors: Begum, Musammat Kulsuma; Konja, Daniels; Singh, Sandeep; Chlopicki, Stefan; Wang, Yu
• Is Part Of: Journal of cardiovascular pharmacology. Volume 78(2021)Supplement 6
• Publication Date: 2021-12
• Subjects: SIRT1 -- endothelial dysfunction -- cellular senescence -- arterial aging; Cardiovascular Diseases -- drug therapy -- Periodicals; Cardiovascular System -- drug effects -- Periodicals; Cardiovascular pharmacology -- Periodicals; Cardiovascular agents -- Periodicals; Cardiovascular agents; Cardiovascular pharmacology; Periodicals; 615.7105
• DOI: 10.1097/FJC.0000000000001154
• Languages: English
• ISSNs: 0160-2446

Abstract

Abstract : Abstract: SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities preventing vascular aging. The expression and function of SIRT1 in endothelial cells are downregulated with age, in turn causing early vascular aging and predisposing various vascular abnormalities. Overexpression of SIRT1 in the vascular endothelium prevents aging-associated endothelial dysfunction and senescence, thus the development of hypertension and atherosclerosis. Numerous efforts have been directed to increase SIRT1 signaling as a potential strategy for different aging-associated diseases. However, the complex mechanisms underlying the regulation of SIRT1 have posed a significant challenge toward the design of specific and effective therapeutics. This review aimed to provide a summary on the regulation and function of SIRT1 in the vascular endothelium and to discuss the different approaches targeting this molecule for the prevention and treatment of age-related cardiovascular and cerebrovascular diseases.