Direct C−H Functionalization of Calix[n](het)arenes (n=4, 6): A Brief Update. Issue 12 (28th March 2022)

• Record Type: Journal Article
• Authors: Mukherjee, Anindita; Kopchuk, Dmitry S.; Kovalev, Igor S.; Santra, Sougata; Varaksin, Mikhail V.; Zyryanov, Grigory V.; Majee, Adinath; Chupakhin, Oleg N.; Charushin, Valery N.
• Is Part Of: ChemistrySelect. Volume 7:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-28
• Subjects: calix[n]arenes -- functionalization -- host-guest properties -- macrocycles -- supramolecular chemistry; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202103017
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Calix[4]arenes are, probably, the mostly explored macrocycles in the supramolecular chemistry. By means of the synthetic modification/functionalization of the upper or lower rims, as well as meso ‐positions, the "host‐guest" properties of these macrocycles can be modulated in order to accommodate the guest molecules of various sizes and nature for supramolecular and coordination chemistry, and to perform various functions for materials science and for biomedical applications. In this review, we wish to highlight the most prospective synthetic approaches for the direct C−H functionalization of calixarene core with various functional moieties. Depending on the nature of the functional moiety these calix[4]arenes can serve as drug carriers and nano‐containers for the recognition, encapsulation or storage of bioactive molecules and for many other applications. Current review article deals with the recent examples of C(H)‐functionalization of calix[4]arenes, as well as selected patterns of direct C(H)‐modification of some calix[6]arenes and calix[4]pyrroles. Abstract : Calix[n]arenes, their hetero derivatives, are the most popular hosts for the supramolecular and materials chemistry as they can form stable inclusion complexes with charged or neutral molecules, including gases. This short review highlights the most prospective synthetic approaches for direct modification of calix[4]arene core with various functional moieties as well as selected patterns of direct C−H‐modification of calix[6]arenes and calix[4]pyrroles.