High-fat/high-carbohydrate-diet short- and middle-term effects on gerbil adrenal zona fasciculata histology. (April 2022)

• Record Type: Journal Article
• Authors: Bellahreche, Zineb; Semiane, Nesrine; Mallek, Aicha; Dahmani, Yasmina
• Is Part Of: Tissue & cell. Volume 75(2022)
• Publication Date: 2022-04
• Subjects: Gerbil -- Obesity -- Adrenal histology -- GLCM texture -- Fractal dimension; Cytology -- Periodicals; 571.5
• DOI: 10.1016/j.tice.2022.101729
• Languages: English
• ISSNs: 0040-8166

Abstract

Highlights: Gerbil adrenal gland histological features. Use of gray level co-occurrence matrix texture and fractal dimension to examine the zona fasciculata. Gerbillus gerbillus as a model of central obesity. Adrenal gland adaptation to high-fat/high-carbohydrate diet. Abstract: The adrenals synthesize many hormones involved in the regulation and maintenance of homeostasis. To understand the pathophysiological changes during the development of obesity, a histological study of the adrenal was performed in gerbils receiving a high-fat/high-carbohydrate-diet (HFC) for 8 or 12 weeks. Compared to the controls, the HFC diet increased body weight. Our results reveal significant weight and structural changes in the HFC group's adrenal glands (confirmed by gray level co-occurrence matrix texture and fractal analysis), disorganization of zona fasciculata (8 weeks) and hyperplasia and peri-capillary fibrosis (12 weeks). In conclusion, these results show that an HFC induces time-dependent structural lesions of the adrenals in gerbils, which could be a sign of chronic adaptation of these glands.