Mesoporous silica nanoparticle-embedded lanthanide organic polyhedra for enhanced stability, luminescence and cell imaging. Issue 12 (8th March 2022)

• Record Type: Journal Article
• Authors: Lin, Xiao-Shan; Yu, Yanzi; Zhou, Li-Peng; He, Lizhen; Chen, Tianfeng; Sun, Qing-Fu
• Is Part Of: Dalton transactions. Volume 51:Issue 12(2022)
• Page Start: 4836
• Page End: 4842
• Publication Date: 2022-03-08
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt04313g
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : We report here a simple but efficient "ship-in-a-bottle" strategy for increasing the stability and luminescence of LOPs by embedding them into MSNs. The biotin-modified Eu8 L12 @MSNs-biotin has been successfully applied in cancer cell targeted imaging. Abstract : We report here a simple but efficient "ship-in-a-bottle" synthetic strategy for increasing the stability and luminescence performance of LOPs by embedding them into mesoporous silica nanoparticles (MSNs). Three types of hybrid materials, i.e. Eu8 L12 @MSNs, Eu8 L12 @MSNs-NH2 and Eu8 L12 @MSNs-biotin, have been prepared and characterized by FT-IR, TGA, SEM and TEM. Photo-optical measurements confirmed that the photoluminescence quantum yields in water have been greatly improved from 5.50% for pristine Eu8 L12 to 44.04% for Eu8 L12 @MSNs-biotin, along with fast disassembly for the former and the optical performance has been maintained for the latter under acidic conditions (pH = 4). Moreover, compared to Eu8 L12, Eu8 L12 @MSNs and Eu8 L12 @MSNs-NH2, the biotin-modified hybrid material Eu8 L12 @MSNs-biotin has exhibited much enhanced fluorescence-imaging ability toward the MDA-MB-231 human breast cancer cells, with significantly reduced dosage of the complex. Our work provides a useful strategy for the functionalization of multinuclear lanthanide organic assemblies toward their biosocial applications.