Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State. (24th June 2021)

• Record Type: Journal Article
• Authors: McEwen, Abbye E; Cohen, Seth; Bryson-Cahn, Chloe; Liu, Catherine; Pergam, Steven A; Lynch, John; Schippers, Adrienne; Strand, Kathy; Whimbey, Estella; Mani, Nandita S; Zelikoff, Allison J; Makarewicz, Vanessa A; Brown, Elizabeth R; Bakhash, Shah A Mohamed; Baker, Noah R; Castor, Jared; Livingston, Robert J; Huang, Meei-Li; Jerome, Keith R; Greninger, Alexander L; Roychoudhury, Pavitra
• Is Part Of: Clinical infectious diseases. Volume 74:Number 6(2022)
• Page Start: 1089
• Page End: 1092
• Publication Date: 2021-06-24
• Subjects: SARS-CoV-2 -- vaccine breakthrough -- variants of concern -- sequencing; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab581
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1–23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections ( P < .05).