Severe Cholestatic Hepatitis Secondary to SARS-CoV-2. Issue 3 (28th March 2022)

• Record Type: Journal Article
• Authors: Lindholm, Christopher R.; Zhang, Xiaofei; Spengler, Erin K.; Daniel, Kimberly E.
• Is Part Of: ACG Case Reports Journal. Volume 9:Issue 3(2022)
• Page Start: e00753
• Publication Date: 2022-03-28
• DOI: 10.14309/crj.0000000000000753
• Languages: English
• ISSNs: 2326-3253

Abstract

ABSTRACT: Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation.