Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters. Issue 24 (4th March 2022)

• Record Type: Journal Article
• Authors: Deng, Zhixin; Han, Sheng; Ke, Miaolin; Ning, Yingtang; Chen, Fen-Er
• Is Part Of: Chemical communications. Volume 58:Issue 24(2022)
• Page Start: 3921
• Page End: 3924
• Publication Date: 2022-03-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc00228k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A series of diphosphine ligands derived from bis[2-(diphenylphosphino)ethyl]amide have proved to be powerful for the linear selective Pd-catalyzed hydroesterification of vinyl arenes. Abstract : Palladium-catalyzed linear-selective hydroesterification of vinyl arenes with alcohols enabled by diphosphine ligands derived from bis[2-(diphenylphosphino)ethyl]amides has been developed. A variety of 3-arylpropanoate esters were obtained in high yields and regioselectivity. The robustness of this methodology was further demonstrated by the efficient gram-scale synthesis of the ethyl 3-phenylpropanoate as a precursor to hydrocinnamic acid.